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| Career Post-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | IP | Last Year | Single Season Leaderboard |
| 1. | Richard Eaker | 36 | 25.7 | 2000 | |
| 2. | Jose Valdovinos | 32 | 28.0 | 2000 | |
| 3. | Keenan Brochu | 27 | 23.7 | 2000 | |
| 4. | Sauron Evil | 21 | 23.0 | 2000 | |
| 5. | George Harmon | 19 | 14.7 | 2000 | |
| Alfred Raskin | 19 | 13.0 | 2000 | ||
| 7. | Brian Valero | 18 | 23.7 | 2000 | |
| 8. | Jeeves Van Hooten | 17 | 26.0 | 2000 | |
| 9. | Malik Meng | 16 | 22.7 | 2000 | |
| 10. | Vincent Marguez | 14 | 13.7 | 2000 | |
| 11. | Rene Mills | 12 | 18.0 | 2000 | |
| Tyrell Silvera | 12 | 15.7 | 2000 | ||
| Joey Barros | 12 | 6.3 | 2000 | ||
| 14. | Armand Banuelos | 11 | 20.0 | 2000 | |
| 15. | Gerald Johnson | 10 | 23.0 | 2000 | |
| 16. | Darius Glover | 9 | 15.0 | 2000 | |
| Aaron Bacon | 9 | 14.7 | 2000 | ||
| Sergio Martinez | 9 | 7.0 | 2000 | ||
| Chung Westbrook | 9 | 5.7 | 2000 | ||
| 20. | Simon Ramirez | 8 | 7.3 | 2000 | |
| Gregory Hart | 8 | 6.0 | 2000 | ||
| Frank Scull | 8 | 4.3 | 2000 | ||
| 23. | Ron Yarbrough | 6 | 12.7 | 2000 | |
| Steven Stockwell | 6 | 10.3 | 2000 | ||
| Aaron Watson | 6 | 8.7 | 2000 | ||
| Abram Barboza | 6 | 8.0 | 2000 | ||
| 27. | Malcolm Yokum | 5 | 8.7 | 2000 | |
| Mario Espana | 5 | 7.3 | 2000 | ||
| Connie Christensen | 5 | 7.3 | 2000 | ||
| Dale Vance | 5 | 7.3 | 2000 | ||
| Samson Steele | 5 | 7.0 | 2000 | ||
| 32. | Jeffrey Cargo | 4 | 8.0 | 2000 | |
| Jeffery Dickerson | 4 | 7.7 | 2000 | ||
| Ralph Harden | 4 | 6.3 | 2000 | ||
| Frankie Maria | 4 | 5.7 | 2000 | ||
| James Rester | 4 | 5.0 | 2000 | ||
| Burton Imes | 4 | 5.0 | 2000 | ||
| Terrence Fitzgibbons | 4 | 4.0 | 2000 | ||
| Blaine Titsworth | 4 | 3.7 | 2000 | ||
| Christian Moscato | 4 | 2.0 | 2000 | ||
| 41. | Jose Rivero | 3 | 10.0 | 2000 | |
| Leo Quintana | 3 | 8.3 | 2000 | ||
| Robby Butler | 3 | 6.0 | 2000 | ||
| Felix Mendez | 3 | 4.7 | 2000 | ||
| Michael Welch | 3 | 4.3 | 2000 | ||
| Jeromy Tavares | 3 | 4.0 | 2000 | ||
| Angelo Rios | 3 | 2.0 | 2000 | ||
| 48. | Thomas Showers | 2 | 8.0 | 2000 | |
| Hikojirou Harumi | 2 | 6.3 | 2000 | ||
| Alvin Anguiano | 2 | 5.0 | 2000 |
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