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| Career Post-Season Losses Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Losses | IP | Last Year | Single Season Leaderboard |
| 1. | Malik Meng | 3 | 22.7 | 2000 | |
| Rene Mills | 3 | 18.0 | 2000 | ||
| 3. | Richard Eaker | 2 | 25.7 | 2000 | |
| Brian Valero | 2 | 23.7 | 2000 | ||
| Keenan Brochu | 2 | 23.7 | 2000 | ||
| George Harmon | 2 | 14.7 | 2000 | ||
| Burton Imes | 2 | 5.0 | 2000 | ||
| 8. | Jose Valdovinos | 1 | 28.0 | 2000 | |
| Gerald Johnson | 1 | 23.0 | 2000 | ||
| Aaron Bacon | 1 | 14.7 | 2000 | ||
| Ron Yarbrough | 1 | 12.7 | 2000 | ||
| Leo Quintana | 1 | 8.3 | 2000 | ||
| Thomas Showers | 1 | 8.0 | 2000 | ||
| Abram Barboza | 1 | 8.0 | 2000 | ||
| Simon Ramirez | 1 | 7.3 | 2000 | ||
| Connie Christensen | 1 | 7.3 | 2000 | ||
| Samson Steele | 1 | 7.0 | 2000 | ||
| Joey Barros | 1 | 6.3 | 2000 | ||
| Robby Butler | 1 | 6.0 | 2000 | ||
| Frankie Maria | 1 | 5.7 | 2000 | ||
| William Piccolo | 1 | 4.0 | 2000 | ||
| Damien Bloch | 1 | 3.7 | 2000 | ||
| William Enger | 1 | 1.7 | 2000 | ||
| Mark Hutchison | 1 | 0.3 | 2000 |
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